Citeseerx bremsstrahlung imaging using the gamma camera. Pdf planar gamma camera imaging and quantitation of. Imaging and detectors for medical physics lecture 5. Quantitative imaging for targeted radionuclide therapy. Quantitation of 90 y by bremsstrahlung imaging is difficult because of poor image quality that. Effects of collimator on imaging performance of yttrium90. Rong x, du y, ljungberg m, rault e, vandenberghe s, frey ec. Posty90 radioembolisation imaging with bremsstrahlung. I illlll i i i i i bremsstrahlung imaging using the gamma. Comparison of tofpet and bremsstrahlung spect images. Single contiguous images of the whole body can be obtained by scanning the gamma camera across the entire length of the patient. Clinical effects of transcatheter hepatic arterial embolization with holmium166 polyllactic acid microspheres in healthy pigs. The applications of scintigraphy include early drug development and nuclear medical imaging to view and analyse images of the human body or the distribution of. To evaluate performance of the imaging system, a y90 point source was designed in gate simulation.
The first use of an anger camera for bremsstrahlung imaging was reported by kaplan et al. Pet imaging of 90 y 90 y imaging is usually associated with the bremsstrahlung radiographs originating from its beta minus spectrum, which has a high end point energy 2. In this short communication, we present a set of proof of principle. The purpose of this study was to evaluate the feasibility of gamma camera system with cdwo 4 detector for quantitation of y90 bremsstrahlung imaging using a geant4 application for tomographic emission gate. The improvement of 90y bremsstrahlung imaging will. Clarke lp, cullom sj, shaw r, reece c, penney bc, et al. Bremsstrahlung spect or spectct was performed on 42 joints using either a general electric discovery vh milwaukee, wi, usa gamma camera with a 1in.
Planar gamma camera imaging and quantitation of yttrium90 bremsstrahlung fig. Citeseerx document details isaac councill, lee giles, pradeep teregowda. In contrast with the majority of the radionuclides used in nuclear medicine imaging, 90y is effectively a pure beta emitter, i. Bremsstrahlung imaging is a simple imaging technique with a planar gamma camera, and it can visualize the intrahepatic and extrahepatic. Yttrium90 90 y microsphere brachytherapy also referred to as radioembolization is used clinically to treat unresectable liver cancer. Quantitation of 90 y by bremsstrahlung imaging is difficult because of poor image quality that results from septal penetration and scatter secondary to the broad bremsstrahlung energies. The purpose of this study was to evaluate the feasibility of gamma camera system with cdwo 4 detector for quantitation of y90 bremsstrahlung imaging using a geant4 application for tomographic. To demonstrate the feasibility, logistics and quality of imaging of the liver after re with sirspheres using a nontof petct scanner, and comparing the studies to brehmsstrahlung gamma imaging. When a gammacamera is used for imaging with a single photon emitting. Practical reconstruction protocol for quantitative 90y bremsstrahlung.
The imaging system consisted of a siemens single head e. Optimization of the image contrast in spectct bremsstrahlung imaging for selective internal radiation therapy of liver malignancies with. We have developed lowenergy xray cameras and conducted secondary electron xrays of proton 2425 and carbonion imaging 26 using these cameras. Difficulties in imaging 90y using spect arise from its. Quantitative imaging of bremsstrahlung from pure beta emitters is proposed as a means for in vivo management of antibody therapy. Technical considerations of phosphorous32 bremsstrahlung. N2 yttrium90 is a promising radionuclide for radioimmunotherapy of cancer because of its energetic beta emissions.
Since the 1990s, bremsstrahlung imaging is widely performed in clinical routine for posttherapy. Usefulness of bremsstrahlung images after intraarterial y90 resin. The method involves the use of highenergy collimation, an empirically selected broad photon energy window to enhance detector sensitivity, and a wiener restoration filter to compensate. Feasibility of gamma camera system with cdwo4 detector for. Imaging was conducted 2472 hours after the re of the hepatic tumors. Using gamma cameras to assess internal contamination from. This study demonstrates images obtained by 90y bremsstrahlung emission computed tomography bect, and characterizes the system performance of gamma cameras. Tkc integration services, llc 6628 brynhurst drive tucker, georgia 30084. Bremsstrahlung imaging is a simple imaging technique with a planar gamma camera, and it can visualize the intrahepatic and extrahepatic distribution of injected y90 microspheres. Since the 1990s, bremsstrahlung imaging is widely performed in clinical routine for posttherapy check using beta emitter, such as 90 y synovectomy or 90 y liver radioembolisation. Tomographic images of a cylindrical phantom filled with water and containing four cylindrical sources of varying diameter are recorded using two collimators with symmetrical aperture configuration but different borelengths. Cam, siemens medical solutions, germany equipped with medium. The aim of this study was to optimise the parameters affecting the bremsstrahlung scintigraphy of patients injected with strontium89 chloride. Gamma camera imaging of osseous metastatic lesions by.
Bremsstrahlung can have any energy ranging from zero to the. Bremsstrahlung imaging using the gamma camera factors affecting attenuation. Bremsstrahlung photons have continuous energy spectrum shapes with broad energy. Jan 17, 2010 using gamma cameras to assess internal contamination from intakes of radioisotopes prepared by. Tomographic images of a cylindrical phantom filled with. A conventional anger camera is not adapted to bremsstrahlung imaging and, as a result, even using a reduced energy acquisition window, geometric xrays represent bremsstrahlung imaging of pure b minus emitters like 32 p and 90 y is typically performed by using a gamma camera 17, 18. Correlation of clinical outcomes with bremsstrahlung and y90. The purpose of this study was to evaluate the feasibility of gamma camera system with cdwo4 detector for quantitation of y90 bremsstrahlung imaging using a geant4 application for tomographic.
Phantom and clinical evaluation of the effect of full monte. Correlation of clinical outcomes with bremsstrahlung and y. Nov 24, 2010 bremsstrahlung imaging is a simple imaging technique with a planar gamma camera, and it can visualize the intrahepatic and extrahepatic distribution of injected y90 microspheres. T1 planar gamma camera imaging and quantitation of yttrium90 bremsstrahlung. Comparison of tofpet and bremsstrahlung spect images of. A conventional anger camera is not adapted to bremsstrahlung imaging and, as a result, even using a reduced energy acquisition window, geometric xrays represent less than 15% of the recorded events. Using gamma cameras to assess internal contamination from intakes of radioisotopes prepared by.
Usefulness of bremsstrahlung images after intraarterial y90. Bremsstrahlung imaging of pure b minus emitters like 32 p and 90 y is typically performed by using a gamma camera 17, 18. Quantitative bremsstrahlung imaging of yttrium90 using a wiener filter. As a result, contrary to gamma emission imaging where about 60% of the recorded events are geometric grays,geometric xrays in bremsstrahlung imaging. The gamma camera can be used for static imaging studies, in which an image of an unchanging radionuclide distribution can be recorded over an extended imaging time e. Planar gamma camera imaging and quantitation of yttrium90. Bremsstrahlung imaging after intraarterial y90 microsphere treatment is useful, in spite of poor image resolution. Technical considerations of phosphorous32 bremsstrahlung spect imaging after radioembolization of hepatic tumors. In this study, we evaluated feasibility of gamma camera system with cdwo 4 detector for quantitation of y90 bremsstrahlung imaging. Mar 27, 2009 this study demonstrates images obtained by 90y bremsstrahlung emission computed tomography bect, and characterizes the system performance of gamma cameras. To demonstrate the feasibility, logistics and quality of imaging of the liver after re with sirspheres using a nontof petct scanner, and comparing the studies to brehmsstrahlung gamma imaging using a spectct scanner in the same patients. We investigated the crosstalk of 111in gamma ray and 90y bremsstrahlung in the spect imaging using inhouse monte carlo simulation codes 14 and found that the count ratio of 90y bremsstrahlung was only. Bremsstrahlung can have any energy ranging from zero to the maximum ke of the bombarding electrons i.
Optimization of the image contrast in spectct bremsstrahlung. In the first step we analyzed the spectrum of bremsstrahlung radiation in order to determine the suitable range of energy for gamma camera imaging. Bremsstrahlung imaging is a simple imaging technique with a planar gamma camera, and it can visualize the intrahepatic and extrahepatic distribution of injected y microspheres. Now we need to discuss what types of collisions give rise to signi. Development of a yapce camera for the imaging of secondary. Optimal design of anger camera for bremsstrahlung imaging.
Energy window setting was 100 kev 25% which demonstrates optimal resolution characteristic for 32p 16. This increases noise, limits the contrast, and reduces the quantification accuracy. Comptonscattered gamma rays may contaminate the energy window of 90y bremsstrahlung singlephoton emission computed tomography spect. Optimization of energy window for 90y bremsstrahlung spect. Quantitative evaluation of scintillation camera imaging.
The improvement of 90y bremsstrahlung imaging will hence be beneficial to both current and future clinical needs. The lost energy is emitted as xray photons, specifically bremsstrahlung radiation bremsstrahlung is german for braking radiation. Difficult to have internal bremsstrahlung sources, so we use. Accepted manuscript sensitivity improvement of yapce. Planar scintigraphy used in nuclear medicine imaging emission imaging radioactive source inside patients body in both spect and planar scintigraphy radiation source used mainly 99 a 140 kev rays hence the name gamma camera. Liver bremsstrahlung imaging with pure beta emitter. Bremsstrahlung imaging using the gamma camera journal of.
Jan 26, 2020 bremsstrahlung imaging is a simple imaging technique with a planar gamma camera, and it can visualize the intrahepatic and extrahepatic distribution of injected y microspheres. Quantitative comparison of pet and bremsstrahlung spect for. A conventional gamma camera is used for the external imaging of bremsstrahlung generated from pure betaemitters such as phosphorous32 32p. We performed a monte carlo simulation of a gamma camera using the. Bremsstrahlung imaging using the gammacamera factors affecting attenuation. This is the range where we decide to use our window for imaging. To qualitatively evaluate the distribution of delivered radiation to each. International journal of radiation research, april 2014. Bremsstrahlung spect or spectct was performed on 42 joints using either a general electric discovery vh milwaukee, wi, usa gamma camera with a 1. Posty90 radioembolisation imaging with bremsstrahlung spect. Feb 26, 2016 the gamma camera can be used for static imaging studies, in which an image of an unchanging radionuclide distribution can be recorded over an extended imaging time e. Quantitative imaging of beta emitters is important for the in vivo management of antibody therapy using either p. Energy of the bremsstrahlung xrays spreads out to 2.